2112 is divided into seven chapters:
- Part 1 Overture
- Part 2 The Temples Of Syrinx
- Part 3 Discovery
- Part 4 Presentation
- Part 5 Oracle: The Dream
- Part 6 Soliloquy
- Part 7 Grand Finale
In the year 2062, a galaxy-wide war results in the union of all planets under the rule of the Red Star of the Solar Federation. By 2112, the world is controlled by the Priests of the Temples of Syrinx, who determine the content of all reading matter, songs, pictures - every facet of life.
A man discovers a guitar and learns to play different music. When he goes to present this to the priests of the Temples, they destroy the guitar. He goes into hiding and dreams of a world before the Solar Federation. Upon awakening he becomes distraught and commits suicide. As he dies, another planetary battle begins resulting in the ambiguous ending "Attention all planets of the Solar Federation: We have assumed control."
Johnny Napalm, Judy Nails, Austin Tejas, and Echo Tesla find the cave where the Beast had banished the Demi-God of Rock's guitar to. In order to retrieve it, the 4 of them must play all 7 songs in the album. Eventually, they complete all 7 songs and retrieve the guitar.
2112 takes place in venues relative to the story. Overture, Discovery, and Soliloquy take place in the cavern. The Temples of Syrinx, and Presentation take place within the Temples of Syrinx. Oracle and Grand Finale take place in the Starman venue.