Misirlou is a song by Dick Dale, and is the 3rd (or 4th in the Xbox 360 Version) song in the 8th tier, and is known for it's long continuous fast-strumming with a faster tempo and riff than the original. The song sounds very similar to Soy Bomb.
Misirlou is considered by many a very hard song, and is in fact at the last tier of the game, but if you just get a grip of fast strumming, it is pretty easy to beat. The key to beat this song is to just strum quickly by moving the strum bar both up and down as fast as necessary. If you can keep the rhythm, you shouldn't have any problems beating it.
Unlike most cover versions. This version of Misirlou is far from the original version. WaveGroup covered the song based on Greatest Hits 1961-1976.
The second hardest song possible to finish by using the Dualshock controller. Though some players consider this the hardest due most of the notes are repetitive/consecutive while a guitar controller can be strummed with ease, unlike DS which is manual.